Tuesday, February 12, 2013

Mesothelioma & Lung Cancer

Mesothelioma and lung cancer are two conditions most commonly associated with asbestos exposure. Even though they affect different parts of the body, both of these cancers can reduce a patient’s respiratory function and cause a number of other internal complications.
The Department of Health and Human Services, the Environmental Protection Agency and the International Agency for Research on Cancer have all declared asbestos to be a human carcinogen. According to these organizations decades of research, asbestos exposure can lead to the development of both lung cancer and mesothelioma.

Exposure Can Cause Both Asbestos Lung Cancer & Mesothelioma

While mesothelioma occurs in the lining of the lungs (called the mesothelial lining), asbestos lung cancer occurs in the actual lungs. When asbestos is inhaled, it can become trapped within the lungs or its lining. It is difficult to expel these strong fibers from the body, and once they are inhaled or ingested, they can trigger biological changes that cause healthy cells to become cancerous.
A person’s biological response to the fibers is partially determined by a number of factors, such as the length of the fiber, chemistry of the fiber and the area in which the fibers were lodged, immune response, and genetic response to cellular damage. Typically, the higher the level of asbestos exposure, the higher the person’s risk of developing lung cancer becomes.
While smoking can increase a person’s risk for developing lung cancer, the disease can also occur in asbestos-exposed non-smokers. One study found that vermiculite miners who were exposed to tremolite and actinolite asbestos had six times the risk of developing lung cancer as the general population.

Why Pleural Mesothelioma is Called Mesothelioma Lung Cancer

One common misconception about mesothelioma is that it is a cancer of the lung, when it is actually a cancer of the lungs’ mesothelial lining. As a result, pleural mesothelioma is sometimes referred to as mesothelioma lung cancer.

Differences Between Mesothelioma & Lung Cancer

Asbestos exposure can cause both mesothelioma and lung cancer, yet these illnesses occur in different parts of the body. Lung cancer affects the actual lung, while mesothelioma develops in the lung’s covering, known as the pleura.
In most cases of asbestos lung cancer, the cells that line the air passages become cancerous. In mesothelioma, the mesothelial cells that line vital organs become cancerous. Pleural mesothelioma typically spreads along interlobal fissures in the lungs and may invade the subpleural part of the lungs when it metastasizes.
Smoking contributes to a patient’s likelihood of contracting these diseases in different ways as well. While smoking has been shown to increase an asbestos-exposed person’s risk of developing lung cancer, smoking does not increase the risk of mesothelioma. Asbestos-exposed smokers’ lungs may be weakened by cigarette smoke, making them generally more susceptible to lung damage and diseases, but smoking does not increase the risk of mesothelioma.

Diagnosing Mesothelioma & Lung Cancer

Although laws have been enacted to restrict the use of asbestos and reduce the incidence of asbestos-related illnesses, patients continue to be diagnosed with mesothelioma and lung cancer because of the diseases’ long latency periods. Many mesothelioma patients do not display symptoms that warrant medical attention until 20 to 50 years after they were exposed to asbestos. Similarly, most lung cancer diagnoses in asbestos workers are made at least 15 years after exposure to asbestos.
For lung cancer and mesothelioma patients, early diagnosis is crucial to improving prognosis. Patients who develop dyspnea, or shortness of breath, and have a significant history of asbestos exposure, should obtain a chest X-ray and pulmonary function tests to increase the chance of early diagnosis.
Tests used in the diagnosis of lung cancer and pleural mesothelioma may include:
  • Physical examination and consideration of asbestos exposure
  • Pulmonary function tests (i.e. spirometry)
  • Chest X-Ray
  • CT-Scan
  • MRI
  • Biopsy
Chest X-rays are the most commonly used diagnostic tool for revealing pleural changes that may be indicative of asbestos-related lung and pleural diseases.
If you have been diagnosed with mesothelioma and would like additional information about your diagnosis, please fill out the form on this page to receive a free packet of mesothelioma literature.
  1. http://www.atsdr.cdc.gov/toxprofiles/tp61.pdf
  2. http://www.atsdr.cdc.gov/asbestos/medical_community/working_with_patients/docs/overviewclin_32205_lo.pd
  3. http://www.atsdr.cdc.gov/asbestos/medical_community/working_with_patients/
  4. http://www.aafp.org/afp/2007/0301/p683.html
  5. http://www.nhlbi.nih.gov/health/dci/Diseases/asb/asb_whatare.html
  6. http://www.atsdr.cdc.gov/toxprofiles/tp61.pdf
  7. http://www.cancer.org/Cancer/CancerCauses/OtherCarcinogens/IntheWorkplace/asbestos


Mesothelioma is cancer of the mesothelial cells, which are the cells that make up the membrane (lining) that covers the outer surface of most of our body organs.
For example, mesothelioma can develop in the lining covering the lungs.
About 2,000 people in the UK are diagnosed with mesothelioma each year.

What is the cause?

Asbestos is the most common cause of mesothelioma. Most people diagnosed with mesothelioma will have been exposed to this mineral at some point in their life.
Mesothelioma can develop many years (usually 40-60 years) after the initial exposure to asbestos.


The outlook for mesothelioma is poor, because it is usually diagnosed when it is at an advanced stage. Most people diagnosed with mesothelioma will die within three years of being diagnosed. Every year in the UK there are around 1,800 deaths from the condition.
The number of deaths from mesothelioma is expected to rise in the years ahead due to the long gap between exposure to asbestos and the onset of the cancer. Experts believe that by 2050, 90,000 people in the UK will have died as a result of mesothelioma.

Sunday, February 10, 2013

About Asbestosis

Asbestosis is a progressive and irreversible lung condition that typically leads to subsequent respiratory disability. Please click on the following links to find out more about the asbestos lung condition Asbestosis.
Asbestosis is a lung condition, often referred to as a “diffuse pulmonary fibrosis” which results from the inhalation of asbestos fibers. It is one of a number of diseases categorized as occupational lung disease or environmental lung disease. A unique aspect of asbestosis that distinguishes it from other fibrotic diseases (such as silicosis) is the presence of asbestos bodies and fibers in the lung tissue. Additionally, asbestos bodies and fibers have been detected in small numbers beyond the lung: in tonsils, thoracic and abdominal lymph nodes, pleura, peritoneum, liver, spleen, pancreas, kidneys, small and large intestines, esophagus and stomach.
How Did I Get Asbestosis?
Asbestos exposure results from people inhaling fibers that are in the air when they breathe. The people with the heaviest risk of exposure to asbestos are those who work directly with the mineral, whether is mining or processing it, during production of asbestos-containing products, or during installation of asbestos insulation.
Family members of asbestos workers are also at risk of inhaling high doses of asbestos fibers. Every member of the household can become exposed to asbestos by coming in contact with and inhaling asbestos fibers that are unknowingly carried home from work on their family member’s clothing.
Exposure to building materials that contain asbestos, specifically in older building is also a concern. If over a period of time insulation material, floor or ceiling tiles start to decompose, asbestos fibers can become airborne and may pose a serious health threat. In this type of situation, asbestos fibers tend to create a dust composed of tiny particles that can float in the air. However, as long as the material is not damaged or disturbed, such as remodeling or drilling, then the asbestos fibers will not be release into the air and therefore will not pose a threat to human health.
Asbestos contamination can also result from ingesting contaminated food or liquids. It can also be detected in the water supply as well as in the air. Asbestos may be released into the water through erosion or natural deposits, corrosion from asbestos-cement pipes, and disintegration of roofing materials containing asbestos that are then transported into the sewers.
What Are The Clinical Signs Of Asbestosis?
Clinical presentation of this disease may include the following:
* Shortness of breath (dyspnea)
-rarely occurs before a decade of exposure
-appears first only upon exertion and subsequently occurs at rest
* Dry cough
-dry and troublesome cough, perhaps associated with chest pain
* X-Ray changes
-generally beginning with irregular opacities at the bases of the lungs, perhaps extending into the upper zones gradually
* Pulmonary function deficiencies
-typically a pulmonary function test reveals a restrictive lung disease pattern
-there may be a pulmonary function loss before x-ray changes become evident
Other more advanced symptoms of this disease include clubbing of the fingers (increased thickness of the digits and curvature of the nails) and cor pulmonale. Medical monitoring for radiologic changes is key, as persons with asbestosis have an increased risk of developing a malignancy.


Mesothelioma Symptoms

Symptoms of plueral mesothelioma (lining of the chest cavity) include:
  • Cough
  • Difficulty sleeping
  • Fever
  • Pain at the side of the chest or the lower back
  • Pleural effusions (fluid in the chest cavity)
  • Progressive loss of appetite and weight loss
  • Shortness of breath, difficulty breathing
  • Tireness
  • Trouble swallowing
Symptoms of peritoneal mesothelioma (lining of the abdominal cavity) include:
  • Belly Pain
  • Nausea
  • Vomiting
  • Weight loss
If there is reason to suspect you might have mesothelioma, or some other ailment, the doctor will take your medical history and often do a complete physical exam. The exam can help tell if you have fluid in the chest, abdomen, or heart area. This fluid can be a sign of mesothelioma. Then one or more of the methods below can be utilize to determine out if you actually have cancer.
Imaging tests allow the doctor to see a picture of the area in question. These could includex-rays, CT scans (computed tomography), MRI (magnetic resonance imaging), or PET scans.
Fluid or tissue samples may be taken (from the chest, stomach, or heart area) with a needle and sent to the lab to see if cancer cells are present.
Other methods involve making a small cut (incision) in the chest or stomach area and then using a small tube with a video camera to allow the doctor to look directly at the area in question.
In another approach, the doctor can insert a lighted tube through the mouth and into the chest. This is called a bronchoscopy (bron-KOS-kuh-pee). If the tube is placed under the chest bone and then moved down into the chest, it is called a mediastinoscopy (media-stine-AHS-kuh-pee).
Surgery allows the doctor to remove a larger sample of tumor or, sometimes, the whole tumor.
It is often hard to identify mesothelioma by looking only at the cells from the fluid around the lungs, stomach, or heart. So your doctor may want to do other tests as well. Sometimes an electron microscope is used to look at cells in greater detail.


Mesothelioma Treatments

Mesothelioma is a very serious disease and patients and their families should have the support and resources they need to better deal with their diagnosis. The following information should aid patients diagnosed with mesothelioma in determining the best course of treatment:
Traditional Treatments
A mesothelioma treatment used either to remove the tumor or to alleviate pain and suffering. If the cancer is relatively contained, surgery can be used to remove part of the lining of the chest or abdomen. The objective is to remove the cancer cells from the body by removing the tissues with large numbers of cancer cells. If the cancer has spread to several organs, it is impossible to remove all of the tissue infected with cancer. In this case, surgery can only be used to relieve pain and suffering. Types of surgeries incude:
Pneumonectomy - An aggressive surgery in which a lung is removed. It can be performed in two ways:
Traditional Pneumonectomy - Only the disease lung is removed.
Extrapleural Pneumonectomy - When the diseased lung, along with part of the pericardium, part of the diaphragm and the parietal pleura on the same side of the chest is removed.
Palliative Procedures - The goal of these procedures is not to cure the disease, but rather to relieve and/or control symptoms associated with mesothelioma:
Thoracentesis - A procedure where a needle is inserted into the chest cavity either to obtain a diagnosis or to drain the fluid to relieve breathlessness and pain.
Pleurectomy/Decortication - The surgical removal of the pleura which is performed to reduce pain caused by tumor mass or to prevent the recurrence of pleural effusion.
This treatment consists of using drugs to treat the cancer. The drugs can be swallowed in pill form or can be injected by a needle into a vein or muscle. Most of the drugs used in the treatment of lung cancer either directly kill cancer cells or stop them from dividing into new cells. The drug enters the bloodstream and circulates throughout the body to reach and destroy the cancer cells. Chemotherapy targets the entire body and can kill normal cells as well as the diseased cells, causing severe side effects.
Chemotherapy can be used in combination with a variety of drugs to increase the total effect and is often used in combination with other treatments, especially surgery.
Side effects can be wide ranged and include nausea and vomiting, loss of appetite, loss of hair, fatigue, constipation, coughing, decreased appetite and mouth sores. These side effects can be treated and they will usually cease after the treatment has ended.
Radiation therapy is the use of high level radiation to kill cancer cells in a localized area. The radiation injures the cancer cells so they cannot divide or multiply further. With each treatment, more of the cells die and the tumor shrinks. The dead cells are broken down and excreted by the body. Most of the healthy cells are able to recover from this injury, but the damage to them is the cause for the side effects of radiation therapy.
Radiation may be used before surgery to shrink the tumor, after surgery to prevent the cancer from coming back, to prevent the growth of cancer, to treat symptoms, and also in combination with chemotherapy. Radiation therapy is sometimes used as the main treatment of Mesothelioma, especially patients whose general health is too poor to undergo surgery.
Side effects of radiation can be severe. They can include: fatigue, hair loss, skin irritation, nausea, and difficulty breathing.
The process of contacting your doctor in the off office hours needs to be simple and accessible. It should include coverage by a competent oncologist at all times, who can speak with you directly about your medical problem. Most office practices have a doctor on call to take calls from patients 24 hours/day.
Experimental Mesothelioma Treatments
Gene therapy
An experimental medical intervention that involves altering the patient’s genetic material of living cells to fight or prevent disease. The therapy involves injecting a modified gene directly into a patient’s chest cavity. The goal of gene therapy is to supply cells with healthy copies of missing or altered genes. Many different strategies are currently under study.
An experimental therapy that uses the body’s natural defenses to fight cancer. This can include stimulating your own immune system to work harder, or using an outside source, such as man-made immune system proteins. Immunotherapy is usually used in conjunction with another type of therapy.
Photodynamic Therapy
An experimental treatment which combines a photosensitizing agent (a drug activated by light) with a light source to destroy cancer cells. The theory is that the photosensitizing agent collects more readily in cancer cells than in normal cells. Thus, when the agent is subsequently exposed to light, it reacts with oxygen to create chemicals that can kill the cancer cells.


Mesothelioma is a rare form of cancer. It is used to describe a cancerous tumor which involves the mesothelial cells of an organ, usually the lungs or abdominal organs.

The most common type of mesothelioma is the pleural mesothelioma. The pleura is a thin membrane found between the lungs and the chest cavity. It provides a lubricated surface so that the lungs do not chafe against the chest walls. Thus, a pleural mesothelioma is often referred to as a “lung” cancer.

Another form of mesothelioma is the peritoneal mesothelioma. The peritoneum is the membrane that encloses the organs of the abdomen. While peritoneal mesothelioma is less common than pleural mesothelioma, it tends to be more invasive, and may thus result in a shorter life expectancy for the patient. Mesothelioma has also been found in the stomach and other abdominal organs.
Why Me?
A common question posed by persons afflicted with mesothelioma is, “Why did this disease develop in me?” The answer is nearly always the same-exposure to asbestos. When diagnosed in the United States, its onset is typically linked to a history of exposure to asbestos fiber. Asbestos is a mineral that was used for decades as a thermal insulation material. It has been widely known since the 1920’s that asbestos is a carcinogen, which means that it causes cancer in humans. However, asbestos was used as an insulator until the mid-1970’s, and is still present in massive quantities in many buildings today. Unfortunately, in many cases very little exposure is required to set this cancer in motion.

Mesothelioma symptoms can be very general and therefore they are often ignored. In most cases, symptoms for this type of cancer arise 2 to 3 months before the cancer is found.
Management of mesothelioma depends largely on the staging of the tumor. Early diagnosis and surgical intervention may lengthen life expectancy. Depending on the age and physical condition of the patient, however, surgery may not be a viable option. In addition to surgical options, radiation treatment and chemotherapy may be helpful in the overall therapeutic program. Pain management and home care are typical alternatives in the later stages of the disease.
See below to learn about the respective symptoms of each type of mesothelioma.
Peritoneal mesothelioma symtoms include:
- Wight loss
- Vomiting
- Nausea
- Belly pain
Pleural mesothelioma symptoms include:
- Trouble swallowing
- Tireness
- Weight loss
- Progressive loss of appetite’
- Fluid in the ches cavity called “Pleural effusions”
- Pain at the side of the chest or the lower back
- Fever
- Difficulty sleeping
- Cough
Where Do I Go From Here?
After diagnosis, it is important to understand your treatment options. Your doctor or oncologist will provide you with information on the treatments that are available to you.
It is also important to know about your legal rights. If you have mesothelioma, or any other asbestos-related disease, you were most likely exposed to asbestos. Many of the manufacturers of asbestos insulation products knew for decades that asbestos was hazardous, yet made a business decision not to warn people of those hazards. As a result, you may have a right of recovery against those manufacturers, which can help defray the costs of treatment and provide compensation for your pain and suffering.

a patient’s Guide to Mesothelioma

MeSotheLIoMa IS a rare CanCer, with 2,000 to 3,000 new cases
diagnosed each year,  and understanding the disease is important in
making decisions about care and treatment.

MeSotheLIoMa ForMS in the mesothelium,a protective membrane covering internal organs, such as the lungs and heart. The mesothelium is made up of two layers—one surrounding the organ itself and the other  forming an outer sac. Between the layers is a lubricating fluid that lessens friction between the membranes and permits the organs to glide smoothly against each other. This is particularly important to the heart and lungs, because they produce significant movement as they function.Mesothelioma is defined by the site of the primary tumor. Pleural mesothelioma, in which cancer cells surround the lungs and/or the chest wall, accounts for about 85 percent of malignant mesotheliomas. Mesothelioma can also grow across the thin mesothelial
tissue that lines the abdomen (peritoneum) or, rarely, the heart or testicles. Mesothelioma is different from other cancers because it’s tightly linked with an environmental cause—asbestos exposure, which accounts for the majority of cases. Most mesothelioma patients worked or lived in a place where they were exposed
to asbestos. Typical mesothelioma patients worked in shipyards or as miners and are men age 60 and older, but family members of these workers have also developed the disease—many with relatively little direct exposure. Also, because mesothelioma can take decades to develop, most patients are older at diagnosis.
The geographic distribution of this disease is not uniform across the United States, with the highest death rates appearing in the Northeastern states, along the Pacific Coast, and in Illinois, Florida, Wyoming, and Colorado. As with the demographic imbalance, the geographic distribution can also be explained by asbestos exposure—the regions with the highest death rates are (or were) home to either factories that manufactured asbestos-containing products or shipbuilding facilities (asbestos materials were commonly
used as insulation in ships).Although the average patient survives only four to 18 months after diagnosis, and only 10 percent of patients survive at least five years, there have been reports of long-term survivors who have no evidence of disease many years following treatment.

Causes & risk Factors

aSBeStoS expoSUre IS the MoSt CoMMon
cause of mesothelioma. the term “asbestos” actually refers to several minerals with shared properties: long, flexible fibers that are resistant to stretching, heat, and corrosion. It’s because of these properties that asbestos was used in products such as insulation, roofing, floor and ceiling tiles, and brake pads.Though the asbestos industry launched in the late 1800s, scientists didn’t link the mineral to mesothelioma until the 1950s. In the United States, asbestos continued to be mined and used—particularly for insulation—until the 1980s. Of the various types of asbestos, the fibers most commonly used in the United States are chrysotile (white asbestos), crocidolite (blue asbestos), and amosite (brown asbestos). Chrysotile is most widely used because its fibers are curled, a property that makes it less likely to fragment than the other types of asbestos. Crocidolite and amosite are typically used in limited, specialized applications because their needle-like tructure makes them highly susceptible to fragmenting. This is important because if asbestos is easily
crushed, it remains airborne longer, which increases the likelihood of inhaling the fibers that cause mesothelioma. Generally, it takes 20 to 40 years or more for mesothelioma to develop following
asbestos exposure. The exact means by which asbestos causes cancer has not yet been fully
determined, but it is known when asbestos is inhaled, about two-thirds of the fibers are
eliminated from the body by coughing or swallowing. The remaining fibers travel through the airways, and some may reach the alveoli, the tiny air sacs in the lungs. Although the method by which asbestos fibers arrive at the mesothelium is not certain, it is likely that this journey takes years, a belief that fits with the

extended period of time necessary to develop mesothelioma. It has never been established if there are any “safe” levels of asbestos exposure. However, there is at least circumstantial evidence that even low nvironmental levels of asbestos exposure can increase the risk of mesothelioma.
Interestingly, smoking is not a risk factor for mesothelioma. However, smoking does increase the risk of lung cancer, which is frequent in people with asbestos exposure. Thus, people with both a history of smoking
and asbestos exposure have an elevated risk of developing lung cancer—approximately
60-fold higher than nonsmokers with no asbestos exposure.While asbestos is the most common
cause of mesothelioma, certain characteristics of the disease suggest that asbestos exposure is not the only cause. Other suspects include:SIMIan VIrUS 40Due to conflicting research, perhaps the
most controversial link to mesothelioma is exposure to simian virus 40 (SV40), a virus
that contaminated polio vaccines during the 1950s and 1960s. In the ’50s, monkeys were
used to develop a vaccine against polio, but in 1961, it was discovered that these monkeys
were infected with SV40, which meant the polio vaccines were likely contaminated. Shortly
thereafter, animal studies showed that SV40 was capable of causing cancer, producing
significant alarm regarding the cancer-causing potential of the contaminated polio vaccines.

Some research supports the possibility that SV40 and asbestos may work together
to cause mesothelioma. For instance, cells with chromosomal abnormalities (such as
those caused by asbestos exposure) can gain cancer-like characteristics more easily
when infected with SV40 compared to cells with normal chromosomes. erIonIteErionite is a non-asbestos mineral fiber that is similar in physical characteristics to crocidolite. Erionite has been identified as
a cause of mesothelioma based on studies of mesothelioma rates among residents of
Cappadocia, Turkey, where erionite has been used in building materials. Of 141 deaths
in four villages during a four-year period, 24 percent were due to mesothelioma. Erionite
deposits can be found throughout the western United States, primarily in areas with a low
population density. To date, however, there have been no cases of mesothelioma attributed to
erionite exposure in the United States.GenetIC preDISpoSItIonFurther examination of the link between
erionite exposure in Turkey and the high mesothelioma death rate produced evidence
that genetic predisposition might also be a factor in development of the disease.
Although all homes in that region contained similar amounts of erionite, mesothelioma occurred in some homes and not in others. In addition, mesothelioma development followed a dominant genetic inheritance
pattern, in which half of the children of parents with mesothelioma also developed mesothelioma. This pattern is consistent with a single genetic mutation from one

Who’s at Risk?
CanCer patients often wonder why they got the disease. Most cases of mesothelioma
involve asbestos exposure, but you may be unsure when, or even how, your exposure
occurred. Although minute levels of asbestos exist in the air, water, and soil, most people
do not develop mesothelioma from this type of exposure. People who develop the disease
generally have regular asbestos exposure, such as from a job.
In the 1970s, legislation was enacted to protect workers from asbestos exposure, but
prior to that, workers in certain industries may have had regular exposure to asbestos. Some
of these occupations are:n Insulation work in buildings and other
n Demolition work, especially in older buildings
n Drywall workers
n Firefighters
n Automobile mechanics
n Steel mill workers
n Shipyard and shipbuilding trades
n Navy veterans
Family members of asbestos-exposed
workers may develop mesothelioma because
of regular exposure to the fibers brought home
on clothing, shoes, and hair. Regular exposure
may have occurred from tasks such as washing

of the parents causing the disease. While
these observations cannot be considered
conclusive evidence for a genetic
predisposition to mesothelioma, they do
provide reason to further study the role of
genetics as a risk factor.

Diagnosis & Staging

DIaGnoSInG MeSotheLIoMa can be a
complicated process. Symptoms do not typically arise until the disease has reached
the late stages, and when they do arise, most are nonspecific, including weight loss, fatigue,
and night sweats. Depending on the type of mesothelioma, organ-specific symptoms may be present.
For instance, most patients with pleural mesothelioma experience lung-related symptoms, such as consistent chest pain and progressively worsening shortness of breath. The pain is typically caused by
invasion of cancer into the chest wall, and shortness of breath is often caused by pleural effusion (excess fluid in the pleural linings of the lungs). The presence of cough, or coughing up blood, can occasionally occur
with pleural mesothelioma.Proper diagnosis requires a combination of physical, radiological, and pathological
examinations, as well as an accurate patient history, including potential asbestos exposure.For patients with pleural effusions, a sample of the fluid is examined for the presence of malignant cells. In most cases, even when a pleural fluid sample is available, a biopsy of the pleural tissue is required to make a diagnosis. Examination of the biopsy samples includes immunohistochemistry (IHC) tests, in which the samples are processed in a way that allows the pathologist to look for specific signs, called markers, of mesothelioma. There are no known markes that correspond to mesothelioma alone, so in order to diagnose mesothelioma, the pathologist generally evaluates the presence or absence of several markers.

Radiological analysis using contrastenhanced computed tomography (CT)
scan provides a three-dimensional view
of the entire pleural surface. It can help
determine the extent of disease and can aid
the physician in finding the desired tissue
for biopsy. Magnetic resonance imaging
(MRI) and positron emission tomography
(PET) scans may also be used to diagnose
Once the diagnosis is made, the disease
stage is evaluated. As with any type of
cancer, determining the extent of the disease
is used to predict a patient’s outcome and to
determine the best course of treatment.
In stage 1, the disease is confined to
the mesothelium and has not spread to the
lymph nodes or any other organs. Stage 1A
refers to a tumor in the outer layer of the
mesothelium, whereas stage 1B refers to a
tumor that has reached both the outer and
inner layer. Stage 1 is the most treatable,
and patients with this stage disease have the
best prognosis (expected outcome).
Stage 2 disease is characterized by the
spread of cancer beyond the mesothelium
and into the lung tissue and/or diaphragm,
but not yet into the lymph nodes. Patients
with stage 2 mesothelioma may be
candidates for surgical removal of the tumor.
For stage 3 mesothelioma, the cancer has
spread into the fatty part of the mediastinum
(the space behind the breastbone and
between the lungs) and/or to the lymph
nodes within the thorax.
Stage 4 is metastatic disease, where the
cancer has spread to other organs, such as
the heart or opposite lung. The cancer may
also have spread into the peritoneum, to the
lymph nodes, or into the spine.

Finding a

BeCaUSe MeSotheLIoMa IS a rare CanCer,
it requires disease-specific expertise.
Here are some places you can go to find a
mesothelioma specialist:
n Local hospital referral services
n Your nearest National Cancer Institutedesignated cancer center (search by state at
n American Board of Medical Specialties at
n American Medical Association’s
DoctorFinder at webapps.ama-assn.org/
n American Society of Clinical Oncology’s
patient site at www.cancer.net
n American College of Surgeons at
n Mesothelioma Applied Research
Foundation at www.marf.org Once you have found several doctors who seem like a good fit, call and ask a few questions—does the doctor take your insurance, is he or she board certified—before scheduling an appointment to meet and interview the doctor/surgeon.You may also want to get a second opinion. Most oncologists expect their patients to seek second opinions, and many suggest it themselves. If your doctor doesn’t recommend a specialist, you can use the resources listed to find a doctor who can offer a second opinion.Nurse coordinators at large medical centers can be particularly helpful in finding physicians who give second opinions. Support groups and other cancer survivors may also be good sources for recommending

Questions to Ask

prepare for your appointment by formulating
a list of questions to ask. You may want to
divide questions into two categories:
What to aSk the DoCtor
n Do you have experience treating
n How long have you been in practice, and
how many cases of mesothelioma have you
n What types of treatment do you usually
n How many times have you performed the
surgery I need, and what’s your success
n Are you involved in clinical trials and
n Who else will be on my health care team,
and what are their qualifications?
What to aSk YoUrSeLF
n Did the doctor give you a chance to ask
n Did you feel like the doctor was listening to
n Did the doctor seem comfortable
answering your questions?
n Did the doctor talk to you in a way you
could understand?
n Do you feel the doctor respected you?
n Did the doctor ask your preferences for

oncologists and specialists. Keep in mind
that these consultations can be expensive
and may not be covered by insurance.
For some insurance plans, second
opinions are covered or even required before
the plan approves payment for treatment, but
you may be limited to certain physicians or
After you weigh your options, you must
choose your medical team. The comfort level,
treatment options proposed, and medical
expertise should all be evaluated when
making a decision.

treatment options

IMproVeMentS In treatMent have been made in recent years, giving mesothelioma
patients hope. an overview of current and investigational therapies are detailed here.
SUrGerYAlthough complete surgical removal of the
tumor is desired, this is rarely achievable for most patients because microscopic tumor
tissue is generally left behind. However, surgery is still used to treat patients with the
goal of removing the vast bulk of the tumor and thus alleviating symptoms. The surgical
procedures include:
n Video-assisted thoracoscopic (VatS) talc pleurodesis is primarily used to treat pleural
effusions, but a biopsy can be obtained at the same time for diagnostic purposes. With VATS
talc pleurodesis, a camera is inserted into the pleura through a small incision in the chest,
and surgical instruments are inserted through two other incisions. The camera allows the
surgeon to maneuver instruments into the pleural space, where the surgeon first drains
the excess fluid and then blows talc (similar to common talcum powder, but sterilized),
causing an inflammatory reaction that literally glues the lung to the inner surface of the rib
cage. Eventually, scar tissue forms, creating permanent bonds that eliminate the space
in which fluid can develop. This procedure should relieve the shortness of breath that
accompanies pleural effusions.n pleurectomy/decortication (p/D) is
performed with the goal of removing as much of the tumor as possible by removing part of
the pleura as well as the fibrous covering of the lungs, which may restrict lung expansion.

This procedure, which can be performed by VATS or through a larger incision on the side
of the chest, is associated with a number of postoperative complications, including air
leak, bleeding, and pus formation. Conflicting evidence exists regarding the impact of P/D,
with some studies suggesting it prolongs life and others indicating it does not.
n extrapleural pneumonectomy (epp),the most aggressive surgical treatment
for malignant mesothelioma, involves the removal of both layers of the pleura along
with the involved lung, some of the lymph nodes, the diaphragm, and the pericardium
(the latter two are reconstructed with synthetic materials). Although EPP has
inherent dangers, it permits the use of radiation therapy following surgery since the
involved lung has been removed. Evidence suggests radiation after surgery may reduce
recurrence at the original tumor site and
prolong survival in patients with earlystage disease. Chemotherapy is now often
incorporated into the treatment plan as well, either before or after surgery. However,
because of the morbidity and mortality associated with this procedure, EPP is only
performed on patients with early-stage disease, good cardiac health, no history
of certain cardiac or lung surgeries, no significant kidney or liver disease, and little,
if any, chest pain.
raDIatIon therapY
Radiation therapy is generally used to treat localized patches of tumor recurrence
or small areas of tumor left behind after surgery. There is no evidence to suggest
radiation alone improves survival, but it does alleviate pain for approximately half of the

patients receiving it.
The goals of current chemotherapy regimens are to prolong the survival of mesothelioma
patients and improve their quality of life by relieving disease-related symptoms.
The approval of Alimta (pemetrexed) in 2004 has led to the largest improvement in
patient outcomes. When added to cisplatin, Alimta, which works by inhibiting cellular
proteins that stimulate cancerous cells to grow, was shown in a clinical study to prolong
average survival by almost three months. Alimta also relieved pain and shortness
of breath, and improved lung function in some patients. Alimta plus cisplatin given
intravenously once every three weeks has become standard therapy for newly diagnosed
mesothelioma. (Clinical studies of Tomudex [raltitrexed], a drug in the same class as
Alimta, have also shown improved response rates and survival times when given with
cisplatin compared with cisplatin alone.)Premedication with folic acid and vitamin
B12 is necessary when taking Alimta in order to reduce the frequency of side effects,
which can include fatigue, nausea, vomiting, anorexia (loss of appetite), constipation,
mouth sores, and low blood cell counts. More severe side effects, including renal failure and
hearing loss, occur in rare instances.
InVeStIGatIonaL therapIeSA number of important mesothelioma
studies were presented at the 2009 annual meeting of the American Society of Clinical
Oncology. A phase III trial comparing Adriamycin (doxorubicin) with or without the

experimental drug Onconase (ranpirnase), showed the average survival of both groups
was nearly identical: 10.7 months for the Onconase group versus 11.1 months for
patients receiving Adriamycin alone. However,
when investigators looked only at patients who had already received one course of
chemotherapy, they found that those patients survived longer, on average, when Onconase
was added to treatment: 10.5 months for the Onconase group versus nine months for
patients receiving Adriamycin alone. Also presented at ASCO’s annual meeting
were results from studies with the targeted agents cediranib and NGR-hTNF, both of
which target the tumor’s blood supply. Cediranib and NGR-hTNF were examined
as single agents, and both demonstrated the ability to slow disease progression in
patients with relapsed mesothelioma. As a result of these findings, new clinical trials are
being planned.
An ongoing phase III trial is investigating Zolinza (vorinostat), which is already
approved for a rare type of lymphoma, to see if it improves survival of patients with
mesothelioma. In this trial, patients whose disease progressed after treatment with
Alimta will be given either Zolinza or placebo. New treatments in phase II development
include drugs approved by the Food and Drug Administration for other cancers—Sprycel
(dasatinib), Velcade (bortezomib), Sutent (sunitinib), Afinitor (everolimus), and Eloxatin
(oxaliplatin)—as well as investigational drugs that are not approved (pazopanib,
vandetanib, and vatalanib).Find ongoing mesothelioma clinical trials at

Legal Issues

CoMpanIeS InVoLVeD In the ManUFaCtUre and distribution of products containing asbestos
can be held liable for the development of mesothelioma in workers exposed to asbestos.
Statutes of limitations vary from state to state and may limit the time in which
you can file a lawsuit after diagnosis. The limitation period can be as short as one
year or as long as three years or more, but the sooner you start the legal process, the
sooner you will receive compensation to help with medical bills and other expenses. Your
case may be expedited depending on your symptoms and the stage of the disease.
The most common types of lawsuits include:n personal injury: These lawsuits are filed
for personal suffering and pain associated with the illness, which can occur from direct
or secondhand exposure to asbestos. Compensation is based on the degree of
incapacity, loss of income, and quality of life related to mesothelioma symptoms and
treatment. Damages are awarded for medical expenses, lost wages, lost prospects, travel
expenses for treatment, pain, and suffering.n Wrongful death: This type of lawsuit
is filed on behalf of the family after the patient’s death. The damages awarded are
for payment of mesothelioma-related medical bills, lost income, counseling related to the
patient’s death, legal advice, personal loss, and other illness-related services.
Choosing an attorney is a personal decision, just as when choosing a medical
team. You should feel comfortable with the answers you receive to your questions, the
way you are treated by the attorney and staff, the level of experience and positive

outcomes the law firm has had with other mesothelioma and asbestos-related cases,
and the firm’s reputation. A word of caution: An attorney should never promise you a
specific amount of compensation. There are no guarantees; each case is unique.
Legal advice and the process of filing a lawsuit is an expensive undertaking.
Most attorneys accept a case based on a contingency fee, meaning you will have no
out-of-pocket expenses and the attorney will receive a percentage of your settlement money
as payment. The contingency fee pays for legal work done on your behalf, court filing fees,
expert witness fees, and legal representation in court. If an award is not granted, you may
be responsible for some expenses depending
on the contingency fee agreement. Once you decide to hire an attorney, you
will meet with the legal staff to provide information about your work history and
personal history to determine the type and degree of asbestos exposure you sustained.
Authorizations will be obtained to get copies of your medical records, and you should not
have to undergo any further medical testing for the purposes of the lawsuit.
Next, you will be asked to give a deposition (getting your testimony on tape) in case
you are not able to appear in court. Some attorneys also have a videographer follow
you for a day to document what a typical day with mesothelioma is like for you. This can be
shown in court to support your case.Many patients worry that with a lengthy
litigation process, they may die before the case is settled. If you pass away, your loved
ones can continue to litigate in your place if you have designated an executor of your
estate and beneficiaries in your will.

preparing for
end of Life

enD oF LIFe Care FoCUSeS on
comfort and symptom relief, while incorporating spiritual and psychological counseling to help
prepare for a good death. Preparing for death also involves drawing up
legal documents, such as a health care power of attorney and living will. With a health care
power of attorney, you will want to choose a person to make medical decisions and initiate
your care plan when you are no longer able to speak for yourself. Sometimes close family
members are not able to separate emotions from logic and may have difficulty carrying
out your wishes, so discuss your wishes with your appointee to verify his/her cooperation
and comfort with serving as your health care power of attorney.
A living will, sometimes referred to as an advance directive, defines what, if any,
extraordinary measures a person would want to be taken to prolong his or her life.
Many of the documents you’ll need can be found at www.caringinfo.org, a website run
by the National Hospice and Palliative Care Organization.Hospice services are designed to provide
symptom relief, pain management, and support to patients and their families. A
person is referred to hospice services when life expectancy is less than six months. Most
hospice services take place in patients’ homes, assisted living facilities, or nursing
homes.Depending on where you live, you may have
multiple options when choosing a hospice provider. Just as carefully as you chose the
health care team to treat your mesothelioma, you will want to do the same in selecting a
hospice provider. Set up an interview and start by asking the following questions:

n Does the provider serve the area in which you live?
n How long has the provider been in operation?
n Does Medicare certify the provider?
n Does the provider accept Medicaid?
n Does your insurance cover the provider?
n Is the provider licensed by the state?
n What additional services does the provider cover, such as follow-up phone calls,
mailings, support groups, and retreats or
activities for families?
n What services, if any, are not provided?
n Is participation in care by a family member required for enrollment in services?
n What is expected from the family
n What, if any, out-of-pocket charges can be
n How flexible is the schedule of visits?
n Who provides the on-call coverage?
n Does the provider have a residential
n What types of services are provided for
funeral arrangement support?
n How are bereavement services managed,
and how long do they last?
After answering your questions, if you are
still uncertain whether the provider is right for
you, you can request an evaluation visit. This
will give you the chance to interact with the
staff in a comfortable environment and get a
better idea of how the services will work. You
may also want to research the reputation of
the agency by asking your doctor, a chaplain,
other health care professionals, and families of
previous patients for advice and information


asbestos Disease awareness organization
Provides education and advocacy on behalf of
asbestos victims.
Cancer Legal resource Center
213-THE-CLRC (743-2572)
Provides information on cancer-related legal
issues for cancer patients and their families.
hospice Foundation of america
Offers practical information about coping with
death and grief, a blog, and teleconferences.
Mesothelioma applied research Foundation
Provides education, support, and advocacy
for mesothelioma patients. MARF also funds
research and has established a grant program to help newly diagnosed patients travel
to consult with an expert.
national association of hospital hospitality
Provides accommodations for patients receiving medical treatment away from home.
national hospice and palliative Care
The NHPCO is an association of programs
that provide hospice and palliative care.
For additional resources, visit www.cure


asbestos > A group of minerals that take the form of tiny fibers. Loose asbestos fibers breathed into the lungs can cause lung
cancer and malignant mesothelioma.Malignant mesothelioma > A rare type of
cancer in which malignant cells are found in the lining of the chest or abdomen.
Mesothelium > A membrane that covers and protects most of the internal organs. The
mesothelium produces a lubricating fluid that allows moving organs to glide easily against
adjacent structures. The mesothelium has different names, depending on its location
in the body.pericardium > The thin layer of tissue that
forms a sac surrounding the heart.
peritoneum > The tissue that lines the abdominal wall and covers most of the organs
in the abdomen.
pleura > A thin layer of tissue that covers the
lungs and lines the interior wall of the chest
SOURCE: National Cancer Institute
. . . . .
Content by Jennifer Klem, PhD, Nanette LavoieVaughan, MSN, APN, and Lena Huang
Cover Illustration by Jan Pults
Published in CURE Fall 2009
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